Synaptic plasticity in medial vestibular nucleus neurons: comparison with computational requirements of VOR adaptation

Background: Vestibulo-ocular reflex (VOR) gain adaptation, a longstanding experimental model of cerebellar learning, utilizes sites of plasticity in both cerebellar cortex and brainstem. However, the mechanisms by which the activity of cortical Purkinje cells may guide synaptic plasticity in brainstem vestibular neurons are unclear. Theoretical analyses indicate that vestibular plasticity should depend upon the correlation between Purkinje cell and vestibular afferent inputs, so that, in gain-down learning for example, increased cortical activity should induce long-term depression (LTD) at vestibular synapses. Methodology/Principal Findings: Here we expressed this correlational learning rule in its simplest form, as an anti-Hebbian, heterosynaptic spike-timing dependent plasticity interaction between excitatory (vestibular) and inhibitory (floccular) inputs converging on medial vestibular nucleus (MVN) neurons (input-spike-timing dependent plasticity, iSTDP). To test this rule, we stimulated vestibular afferents to evoke EPSCs in rat MVN neurons in vitro. Control EPSC recordings were followed by an induction protocol where membrane hyperpolarizing pulses, mimicking IPSPs evoked by flocculus inputs, were paired with single vestibular nerve stimuli. A robust LTD developed at vestibular synapses when the afferent EPSPs coincided with membrane hyperpolarisation, while EPSPs occurring before or after the simulated IPSPs induced no lasting change. Furthermore, the iSTDP rule also successfully predicted the effects of a complex protocol using EPSP trains designed to mimic classical conditioning. Conclusions: These results, in strong support of theoretical predictions, suggest that the cerebellum alters the strength of vestibular synapses on MVN neurons through hetero-synaptic, anti-Hebbian iSTDP. Since the iSTDP rule does not depend on post-synaptic firing, it suggests a possible mechanism for VOR adaptation without compromising gaze-holding and VOR performance in vivo

Are Protective Labor Market Institutions Really at the Root of Unemployment? A Critical Perspective on the Statistical Evidence

This report debunks the myth that labor market protections, such as unions and unemployment benefits, are responsible for high European unemployment rates.

Programming Idioms for Transactional Events

Transactional events (TE) are an extension of Concurrent ML (CML), a programming model for synchronous message-passing. Prior work has focused on TE's formal semantics and its implementation. This paper considers programming idioms, particularly those that vary unexpectedly from the corresponding CML idioms. First, we solve a subtle problem with client-server protocols in TE. Second, we argue that CML's wrap and guard primitives do not translate well to TE, and we suggest useful workarounds. Finally, we discuss how to rewrite CML protocols that use abort actions

COMPLIANCE TESTING OF IOWA’S SKID-MOUNTED SIGN DEVICE

A wide variety of traffic control devices are used in work zones, some of which are nont ormally found on the roadside or in the traveled way outsideofthe work zones. These devices are used to enhance the safety of the work zones by controlling the traffic through these areas. Due to the placement of the traffic control devices, the devices themselves may be potentially hazardous to both workers and errant vehicles. The impact performance of many work zone traffic control devices is mainly unknown and to date limited crash testing has been conducted under the criteria of National Cooperative Highway Research Program (NCHRP) Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The objective of the study was to evaluatethe safety performance of existing skid-mounted sign supports through full- scale crash testing. Two full-scale crash tests were conducted on skid-mounted sign supports to determine their safety performance according to the Test Level 3 (TL-3) criteria set forth in the NCHRP Report No. 350. The safety performancevaluations indicate that these skid-mounted sign supports did not perform satisfactorily in the full-scale crash tests. The results of the crash tests were documented, and conclusions and recommendations pertaining tothe safety performance of the existing work zone traffic control devices were made

SINGLE-SIDED CRASH CUSHION SYSTEM

A single-sided crash attenuation cushion system having an impact head and three stage energy absorption mechanism. The energy absorbing mechanism has a mandrel for deforming thin-walled tubes in a controlled collapse to absorb impact forces from a colliding vehicle. The third stage of the absorption mechanism includes an additional deformable compressible tube between the fixed-object hazard and the thin walled tubes

ENERGY ABSORBING BREAKAWAY STEEL GUARDRAIL POST

An improved breakaway steel guardrail post for use in dissipation of impact energy upon impact of the post having an upper post member and a lower post member, a connecting joint, and a mechanism connected to the upper and lower post members for controlling the energy dissipation of the guardrail post about the connecting joint at a predetermined rate. A first embodiment utilizes a cable restraint lopped through openings in he guardrail posts. Other embodiments included straps and fasteners disigned to distort or fail at predetermined rates or strengths and combinations thereof

ENERGY ABSORBING BREAKAWAY STEEL GUARDRAIL POST

An improved breakaway steel guardrail post for use in dissipation of impact energy upon impact of the post having an upper post member and a lower post member, a connecting joint, and a mechanism connected to the upper and lower post members for controlling the energy dissipation of the guardrail post about the connecting joint at a predetermined rate. A first embodiment utilizes a cable restraint lopped through openings in he guardrail posts. Other embodiments included straps and fasteners disigned to distort or fail at predetermined rates or strengths and combinations thereof

CRASH ATTENUATION SYSTEM

A crash attenuation system having an impact head, and energy absorption mechanism. The energy absorbing mechanism has a mandrel for rupturing thin-walled tubes in a controlled rupture to absorb impact forces from a colliding vehicle. A frame may be used to mount the system to a truck, trailer, guardrail, median barrier end treatment, or a crash cushion. Stress concentrators may be incorporated into the tubes and the mandrels to selectively control rupturing and energy dissipation